Our group recently published that infection of human adenoviruses (HAdV), which are known to extensively interact with PML-NBs [reviewed in reference (50)], can be potently inhibited by treatment with arsenic trioxide (ATO/As2O3), mainly by interference with HAdV-induced PML-NB relocalization, disruption, and deregulation of the cellular SUMO pool (51). The gene discussed is PML; the disease is infection.