CASP3 and neoplasm: 4-dmH treatment was associated in vivo with upregulations of pro-apoptotic Bak and caspase 3-directed PARP cleavage, and the concurrent downregulation of anti-apoptotic Flip (Figure 10c), suggesting that the greater inhibition of tumor volume by this water-soluble derivative of heliomycin was related to apoptosis induction.