ENOX2 and cancer: tNOX exhibits relatively low expression in non-transformed cells, but is highly correlated with the hallmarks of cancer cells; positively regulates cell proliferation, and its downregulation is associated with cell-death-related pathways (Hostetler et al., 2009; Sumiyoshi et al., 2022; Liu et al., 2008; Ronconi et al., 2016).