ENOX2 and lip and oral cavity carcinoma: Taken together, our present results show that the superior anticancer activity of 4-dmH over its parental heliomycin resides in its direct targeting of tNOX and SIRT1, and suggest that the tNOX-NAD+-SIRT1 regulatory axis contributes to inducing apoptosis independent of p53 status, as evidenced by the results of in vitro and in vivo studies of oral cancer.