SIRT1 and lip and oral cavity carcinoma: Considering that tNOX not only supports but also exerts functions independent of SIRT1, the tNOX- and SIRT1-inhibiting function of 4-dmH, thus, results in the different biological outcomes from the SIRT1-binding heliomycin, as evidenced by the results of in vitro and in vivo studies of oral cancer.