Our preliminary results confirm that three asthma susceptibility loci: 2q12.1 (IL1RL1), 6p21.32 (HLA-DQA1/B1/A2/B2), and 22q12.3 (IL2RB) each have VDR- and IKZF3-binding sites either in enhancers predicted by GeneHancer to target these genes or within these genes themselves. The gene discussed is IL1RL1; the disease is asthma.