These same four SNPs in 17q12-21.1 were also in high-LD with two SNPs in ZPBP2 and ORMDL3 (rs12936231 and rs4065275, respectively) that were previously shown to be functionally relevant to asthma (Kelly et al., 2019; Schmiedel et al., 2016; Verlaan et al., 2009). This evidence concerns the gene ORMDL3 and asthma.