Two SNPs in ZPBP2 and ORMDL3 (rs12936231 and rs4065275, respectively) that were previously shown to be functionally relevant to asthma (Kelly et al., 2019; Schmiedel et al., 2016; Verlaan et al., 2009), were also in high-LD with the four SNPs that we identified in the VDR-binding regions of the 17q12-21.1 loci (Figure 1C). This evidence concerns the gene ZPBP2 and asthma.