LCN2 and infection: While we did not detect significant differences in tissue IL-10 production (Fig. 1d) or Il-10 expression (data not shown) from infected animals treated with Lcn2 compared to vehicle controls, it remains possible that even with the potentiating effects of Lcn2 on Cxcr2 expression, its actions on macrophages and subsequent influence on immune responses that promote infection establishment and persistence may overshadow any protective effects on neutrophil chemotaxis and activation due to Cxcr2 induction.