This study predicted that linalool, p-cymene, α-terpinene, terpinen-4-ol, and α-terpineol primarily contribute to CBEO’s anti-depressant effect, mainly via interactions with OPRM1, PTGS2, ESR1, SLC6A4, DRD2, and NR3C1, the six depression-related targets. Here, PTGS2 is linked to major depressive disorder.