The study by Zhang et al. confirmed that salidroside effectively reduced the protein expression of myostatin, increased the protein expression of myogenin and p-akt protein content, increased cytochrome C oxidase and ATP synthase activities, and enhanced mitochondrial energy metabolism in rats with COPD, thereby improving skeletal muscle dysfunction in rats with COPD, further explaining the rationale for the effect of rhodiogenic on alleviating symptoms in COPD patients (Zhang et al., 2019). Here, MYOG is linked to chronic obstructive pulmonary disease.