Lin et al. found that normal doses of chebulinic acid and andrographolide significantly inhibited HSV-1 invasion into human lung cancer cells A549, mainly by inhibiting the interaction of glycosaminoglycans on the surface of A549 cells with the glycoproteins on the surface of HSV-1 virus, and that chebulinic acid and andrographolide were competitive inhibitors of glycosaminoglycans, thus exhibiting some degree of antiviral effect (Lin et al., 2011). The gene discussed is ART4; the disease is lung cancer.