TP53 and lung cancer: Tian et al. investigated the effect of aqueous extract of myrobalan on the proliferation of human lung cancer A549 cells and showed that the inhibition rate of human lung cancer A549 cells increased when the concentration of aqueous extract of myrobalan increased, and the mRNA expression of P53 protein increased, so the ability of myrobalan extract to induce apoptosis in A549 cells may be related to the activation of P53 gene (Tian et al., 2015).