Over the past few decades, numerous studies have shown the dual effect between ALDH2 gene polymorphisms and cardiovascular diseases: ALDH2 mutation could increase the risk of coronary artery disease, peripheral artery disease and stroke; ALDH2 mutation could also decrease the risk of hypertension and aortic aneurysms or dissections (5). The gene discussed is ALDH2; the disease is coronary artery disorder.