ALDH2 and cardiovascular disorder: Although ALDH2 is well-known for its crucial role in ethanol metabolism, ALDH2 also has other diverse pathophysiological effects: ALDH2 could also metabolize many other short-chain fatty aldehydes and some aromatic and polycyclic aldehydes, which provides essential protective enzyme functions against these toxic substances and potential mechanism of participating in the development of cardiovascular disease (CVD) (3, 4).