The preclinical studies consistently reported positive effects of PBM on metabolic parameters with an improvement in glucose tolerance [with a glucose tolerance test area under the curve (GTT AUC) decreasing by 12–28%], a decrease in insulin resistance [with a 22% decrease in homeostatic model assessment of insulin resistance (HOMA-IR (70)) and a 10% decrease in insulin tolerance test (ITT) AUC (72)] and a decrease in fasting glycemia. Here, INS is linked to Insulin resistance.