Patterns of GM atrophy and tau accumulation are known to differ between non-amnestic AD clinical syndromes and amnestic AD (Ossenkoppele et al., 2015a; Phillips et al., 2018a), but there is less evidence regarding whether patterns of WM degeneration exhibit corresponding phenotypic differences, and whether those WM degeneration patterns reflect the topography of GM disease in each clinical syndrome. The gene discussed is MAPT; the disease is Alzheimer disease.