Furthermore, in the pathophysiological mechanisms involved in MAFLD, pro-inflammatory molecules such as Transforming Growth Factor beta-1 (TGF-β1), Insulin-Like Growth Factor (IGF-1) and endothelin-1 and inflammatory mediators such as C-Reactive Protein (CRP), Interleukin (IL)-6, and pro-coagulant factors such as fibrinogen, factor VIII and plasminogen activator inhibitor-1 (19), which also determine insulin resistance (20) must also be considered. This evidence concerns the gene CRP and Insulin resistance.