Consistent with this finding, previous studies showed that AD occurs when the expression of the outer membrane CXCL1/granulocyte colony-stimulating factor drives local neutrophil recruitment, activation, and infiltration (Yoshida et al., 2019), resulting in outer membrane inflammation, aortic dilatation, and rupture via IL-6 production (Anzai et al., 2015). This evidence concerns the gene IL6 and Alzheimer disease.