ROC analysis showed that CASP4 (AUC = 1.0, Figure 12C), PECAM1 (AUC = 1.0, Figure 12D), PKM (AUC = 0.988, Figure 12E), SERPINB1 (AUC = 0.970, Figure 12F), TLR2 (AUC = 0.994, Figure 12G), VEGFA (AUC = 0.994, Figure 12H), and BHLHE40 (AUC = 0.959, Figure 12I) all have good potential to differentiate the AD group from normal controls, suggesting that these genes could serve as potential diagnostic markers for AD in the future. The gene discussed is PKM; the disease is Alzheimer disease.