PPARG, the only key gene that was downregulated in AD, is an anti-inflammatory gene that prevents the degeneration and death of the aortic stroma by inhibiting NF-κ-B-mediated pro-inflammatory responses (Wang M. et al., 2022) and regulates the role of the cardiovascular circadian rhythm (Aicher et al., 2021). The gene discussed is PPARG; the disease is Alzheimer disease.