BHLHE40 and Alzheimer disease: ROC analysis showed that CASP4 (AUC = 1.0, Figure 12C), PECAM1 (AUC = 1.0, Figure 12D), PKM (AUC = 0.988, Figure 12E), SERPINB1 (AUC = 0.970, Figure 12F), TLR2 (AUC = 0.994, Figure 12G), VEGFA (AUC = 0.994, Figure 12H), and BHLHE40 (AUC = 0.959, Figure 12I) all have good potential to differentiate the AD group from normal controls, suggesting that these genes could serve as potential diagnostic markers for AD in the future.