The connections between important (hub) PRGs (BHLHE40, CASP4, PKM, SERPINB1, TLR2, VEGFA) and numerous invading immune cells in AD were generally comparable; however, the correlations between PECAM1 expression and multiple immune infiltrating cells differed from those of the other genes (Figure 10A). This evidence concerns the gene BHLHE40 and Alzheimer disease.