The authors stimulated ILC1s from patients with PMA/ionomycin and cultured them with CLL cells and ILC1s were unable to enhance IFN-γ or TNF production showing a defect in responsiveness of ILCs from cancer patients which suggests an immunosuppressive role for ILC1s in certain cancer environments [66]. The gene discussed is TNF; the disease is B-cell chronic lymphocytic leukemia.