The findings were confirmed in IL-27rα−/− mice, where IL-27Rα−/− mice immunized with IRBP revealed higher EAU scores, severe vasculitis/retinitis and perivascular exudates, lower electroretinogram amplitudes, and greater CD4+IFNγ+, CD4+IL-17A+, CD4+GM-CSF+, CD4+IFNγ+GM-CSF+, and CD4+IL-17A+GM-CSF+ T-cell infiltration in the eyes. Here, CSF2 is linked to vasculitis.