IL-27 gene polymorphisms (rs153109, rs34833, rs26528, rs17855750, rs181206, and rs40837) were not related to T1D risk in Brazil, and IL-27 genetic mutation did not correlate with gender, age at diagnosis of diabetes, and patients with pancreatic and extrapancreatic autoantibodies (170) (Table 2). This evidence concerns the gene IL27 and type 1 diabetes mellitus.