Moreover, the IL-27p28 subunit injected into adjuvant-induced arthritis rats amplified autoantibodies’ production, whereas administration of a targeted DNA vaccine encoding IL-27p28 into the arthritis rats revealed the downregulated form of the disease, less paw swelling, and reduction in inflammatory mononuclear cell infiltration in the synovial membrane; the thickness of the synovial lining, cartilage destruction, expression of collagen type II, and proliferation of Ag-specific T cells were decreased (179). This evidence concerns the gene IL27 and Arthritis.