Interestingly, IL-27rα−/− were induced to experimental allergic conjunctivitis (EAC), showing stronger Th2- and Th17-dominant responses in conjunctiva and cervical lymph nodes, evidenced by the high expression of IL-4, IL-5, IL-13, GATA-3, and IL-17 and the higher percentage of IL-17A+ cells in conjunctival stroma. This evidence concerns the gene IL17A and atopic conjunctivitis.