IL27RA and colitis: B6 DKO mice cotransferred T cells from IL-27rα−/− mice and B cells from WT mice showed signs of colitis, whereas B6 DKO mice cotransferred T cells from IL-27rα−/− mice and B cells from IL-10−/− mice had no features of colitis, demonstrating the role of IL-27 signaling in regulating IL-10-secreting B cells to ameliorate T cell-mediated colitis and contribute to intestinal homeostasis (196).