IL27 and systemic lupus erythematosus: When the patients with SLE were divided into two groups, patients with high type 1 interferon (IFN) signature and patients with type 1 IFN signature similar to the healthy controls, expression of IL-27 was elevated in the patients with high type 1 IFN signature, whereas expression of IL-27 was comparable between patients with type 1 IFN signature similar to the healthy controls and healthy controls, suggesting that the type 1 IFN signature was related to higher levels of IL-27 (122).