In IL-27rα−/−Roquinsan/san mice, there was reduced kidney pathology, such as reduced glomerular and tubulointerstitial nephritis and vasculitis, and there was ameliorated splenomegaly, a lower number of CD4+CXCR5+PD1+ Tfh cells and B220+GL7+CD38lo GC B cells, and a higher percentage of CD138+ plasma cells compared with IL-27rα+/+Roquinsan/san mice (114). Here, CD4 is linked to vasculitis.