PRDM1 and chronic hepatitis B virus infection: T follicular helper (Tfh) cells sorted from patients with chronic hepatitis B (CHB) were primed with HBsAg, and then cocultured with autologous memory and naive B cells in the presence of IL-27 neutralizing antibody, showing more plasmablasts and plasma cell differentiation and less production of B lymphocyte-induced maturation protein-1 (Blimp-1) (70).