LL-IL-27 delivery in TNBS-induced colitis mice also led to increased colon length; decreased serum levels of C-reactive protein (CRP), CXCL1, CXCL2, IL-1α, IL-6, IFNγ, IL-23, IL-17A, and IL-17F; reduced number of IL-17A- and IL-17F-expressing cells; reduced total histology colitis score; and myeloperoxidase+ neutrophil infiltration into the colonic mucosa (198, 199). This evidence concerns the gene IL1A and colitis.