CD276 and esophageal squamous cell carcinoma: Due to the accessibility and specificity of CD276-targeted CAR in former studies (3, 35, 36), we developed the iPSC CD276-targeted CAR-NK cells and appraised their cytotoxicity against CD276-expressing ESCC patient-specific organoids and primary cultured ESCC cells, along with CD276-expressing human ESCC cell line (KYSE-150) in vitro, and in BNDG mouse models.