For instance, an anti-VEGFR2 F(ab′)2 which was conjugated with the mitochondria targeted antioxidant peptide SS31 conferred the advantage of attenuating oxidative stress and better therapeutic response in diabetic nephropathy mice model, validating the effectiveness of bivalent antibody fragments in the development of ADCs for Diabetic nephropathy therapy [40]. This evidence concerns the gene KDR and diabetic kidney disease.