IL33 and Crohn disease: In co-culture with intestinal fibroblasts, IL-33-activated eosinophils led to increased expression of inflammatory cytokines TNF-α, IL-1β, and IL-6 in addition to eosinophil-targeting chemoattractants Eotaxin-2 and -3, providing evidence for an IL-33-eosinophil-fibroblast pathway in stricturing Crohn’s disease [102, 103].