In addition to more severe weight loss, splenomegaly, thrombocytopenia, hyperferritinaemia, and bone marrow hemophagocytosis, IL-18BP−/− mice also have significantly increased circulating IFNγ levels, further supporting a role for IL-18 in driving IFNγ release and ultimately MAS [73]. The gene discussed is IFNG; the disease is Hemophagocytosis.