IL18 and macrophage activation syndrome: For this reason, direct inhibition of the inflammasome may be a beneficial treatment option for patients with cytokine storm-induced MAS as it will prevent pyroptosis, therefore preventing the release of DAMPs that propagate cytokine storms, while also preventing maturation of IL-1β and IL-18, which drive an array of downstream cytokine responses as well as having an impact on the formation of blood clots.