Excessive activation of classical complement components is thought to contribute to cytokine storm and exaggerated pathology in severe COVID-19 disease, suggesting a potential mechanism by which elevated CRP levels after stroke may contribute to increased risk of severe disease [119].However, lectin pathway recognition molecules are able to bind to the SARS-CoV-2 spike and nucleocapsid proteins and activate the alternative arm of the complement cascade and is beneficial for infection clearance [120]. Here, CRP is linked to infection.