A previous study indicated that RACGAP1 regulated the downstream factors of the PI3K/AKT signaling pathway and that the compensatory activation of the PI3K/AKT signaling pathway was closely associated with ADT drug resistance and neuroendocrine differentiation in PCa (Hazar-Rethinam et al., 2015; Song et al., 2023). The gene discussed is AKT1; the disease is posterior cortical atrophy.