For instance, Sierra et.al reported that SMOX participated in Helicobacter pylori‐induced β‐catenin activation in gastric cancer oncogenesis.[24] The byproduct of the SMOX reaction produces the proinflammatory chemokine CXC motif ligand 1 (CXCL1), promoting cell migration.[25] Consistently, we discovered that the YBX1/m5C‐SMOX axis enhanced the ESCC malignant phenotype and was involved in the regulation of proteins associated with EMT and cell stemness maintenance, including MMP1, MMP2, and β‐catenin. Here, MMP2 is linked to esophageal squamous cell carcinoma.