In addition, the expression level of proteins associated with epithelial to mesenchymal transition (EMT) and stemness, including MMP1, MMP2, and β‐catenin, was reduced by YBX1 knockdown, whereas it was significantly increased in ESCC cells overexpressing YBX1 (Figure 2K). Here, MMP1 is linked to esophageal squamous cell carcinoma.