Previous studies indicated the regulatory effect of m5C methylation on mRNAs, which is usually interpreted by reader proteins.[16] As a multifaceted molecule, YBX1 functions as a transcription factor when located in the nucleus,[17] whereas it typically serves as an RNA‐binding protein in the cytoplasm.[10] Numerous studies have reported that YBX1 promotes tumor growth and metastasis in various cancer types including HCC,[8, 18] colorectal cancer,[9] and clear cell renal cell carcinoma.[11] Notably, Chen et al. The gene discussed is YBX1; the disease is cancer.