GRB2 and esophageal squamous cell carcinoma: demonstrated that NSUN2 promoted HCC development by mediating m5C modifications.[20] Furthermore, NSUN2 enhanced the proliferation of gastric cancer cells by destabilizing the m5C‐modified p57Kip2 mRNA.[21] A recent study revealed that NSUN2‐mediated m5C modification of GRB2 mRNA promoted ESCC progression.[22] In accordance with previous studies, our study showed that NSUN2 was upregulated in ESCC tissues.