Previous studies identified LINC00702‐miR‐181b‐5p axis, miR‐127‐5p and miR‐186 affects SPP1 expression in CAVD or OA [54, 57, 61], to the opposite, we identified that lncRNA NEAT1 and lncRNA XIST were key lncRNAs in the network and hsa‐miR‐580‐3p regulated both LRRC15 and SPP1 expression (Figure 11). This evidence concerns the gene XIST and congenital bilateral aplasia of vas deferens from CFTR mutation.