The 6 variables with P values less than 0.05 were included in the multifactorial analysis, and the results are shown in Table 2.Age (OR = 1.034, 95% CI: 1.002–1.067, P = 0.035), diabetes(OR = 2.450, 95% CI: 1.330–4.511, P = 0.047), total albumin(OR = 0.903, 95% CI: 0.837–0.974, P = 0.004), an SII > 752.6 × 109 (OR = 0.311, 95% CI: 0.158–0.614, P = 0.001) and a CRP concentration > 20.25 mg/L (OR = 0.463, 95% CI: 0.256–0.837, P = 0.011) were found to be independent predictors of POD. The gene discussed is CRP; the disease is diabetes mellitus.