CCN5 and colon adenocarcinoma: Although the loss of LATS1/2 or activation of YAP/TAZ promotes cell proliferation in most cell lines, LATS1/2 deletion inhibits the growth of murine colon adenocarcinoma MC38 cells owing to the induction of the cellular growth suppressor WNT1-inducible signaling pathway protein 2 (WISP2) and coiled-coil domain containing 80 (CCDC80) [42].