LATS1 and cancer: For instance, although genetic elimination of the upstream kinase MST1/2 in the mouse liver [26–28] and intestine [38] has been associated with tumorigenesis, deletion of the downstream kinase LATS1/2 in the liver [36, 37], kidney [39], and breast [40] does not lead to cancer development in mice, presenting a compelling contrast in the observed outcomes [41].