Another study showed that the activation of YAP in tumor-initiating cells (TICs) recruits TIC-associated macrophages via the induction of C-C motif chemokine ligand 2 (CCL2) and colony-stimulating factor 1 (CSF1), suppressing the immune clearance of TICs to promote tumorigenesis [79]. The gene discussed is CSF1; the disease is neoplasm.