In the past few decades, some non-insulin based IR (NI-IR) indices, e.g., ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C), TG glucose (TyG) index, metabolic score for IR (METS-IR) and the Zhejiang University (ZJU) index were proposed to show a good correlation to the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and found to be a better indicator of metabolic syndrome than HOMA-IR [11–14]. Here, INS is linked to Insulin resistance.