RNA immunoprecipitation analysis has revealed that the m6A methylation of circCPSF6, mediated by ALKBH5, promotes its interaction with poly(C)-binding protein 2 (PCBP2) to regulate Yes-associated protein 1(YAP1) expression, thereby driving the aggressive viability, migration, and invasion of HCC cells [70]. Here, ALKBH5 is linked to hepatocellular carcinoma.