Compared with normal liver tissues, the SENP1 gene was increased in the HCC of TCGA-LIHC dataset from GEPIA database (Supplementary Fig. 5E), and the negative expression correlation between ANXA6 and SENP1 was obvious in HCC samples from TCGA-LIHC dataset (Supplementary Fig. 5F-G). Here, SENP1 is linked to hepatocellular carcinoma.