We observed a negative association between Hypo-MS4 activity and FOXA1 expression in the TP53-MUT group in 3 out of the 4 mentioned cancer types (LIHC: P = 0.086; BRCA: P = 9.7 \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\times {10}^{-9}$$\end{document}×10-9; HNSC: P = 0.011; Wilcoxon rank-sum test, Fig. 6D and Additional file 1: Fig. S13A). This evidence concerns the gene FOXA1 and cancer.