The interaction between FOXA1 expression and TP53 mutational status was found to be a significant predictor of decreased Hypo-MS4 activity in 3 out of 4 cancer types (LIHC: coeff =  − 97.68, P = 9.4 \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\times {10}^{-4}$$\end{document}×10-4; BRCA: coeff =  − 54.40, P = 0.028; HNSC: coeff =  − 81, P = 0.03; and LUAD: coeff = 7.6, P = 0.8; Additional file 1: Fig. S13C). This evidence concerns the gene FOXA1 and cancer.