We retrieved the FOXA1-binding landscape for the DMPs related to Hypo-MS4 in multiple cancer cell lines (A549, HepG2, T47D and MCF-7) (Fig. 6A and Additional file 1: Fig. S12A, B) and tumor tissues (BRCA and COAD) (Fig. 6B) and showed that the FOXA1-binding affinity selectively peaked at the center of the DMPs. This evidence concerns the gene FOXA1 and neoplasm.