CDKN1A and neoplasm: Among the most conserved and highly weighted genes between the cell-based and tumor methylation signatures were many known oncogenes, such as ETS1, RORA, and CDKN1A (Hypo-MS1); immune genes, such as SIGLEC9, SIGLEC7, MUC15, and LAIR1 (Hypo-MS4); and SEPT9 [49] and DDIT3 [50] (methylation-related biomarkers) for Hyper-MS2.