AIF1 and neoplasm: Notably, certain resting and hyper-ramified morphologies remained detectable, particularly at the invasive front, in areas marked by lower tumor cell density (e.g., PDOXs P8 Fig. 3A; PDOXs T101, T192 Additional file 2: Fig S1B).This was in agreement with increased presence of amoeboid Iba1+ cells concomitant with increased tumor cell density upon tumor growth over time in mice (Fig. 3B).