Gas6 produced by tumor and ependymal cells was predicted to interact with the receptor Mertk in myeloid cells, Tyro3 in tumor cells and Axl in ependymal cells, while additional App-Cd74 signaling axes were predicted between tumor, myeloid, endothelial and ependymal cells (Fig. 7K). The gene discussed is TYRO3; the disease is neoplasm.