Consistent with other reports [32, 33], STZ-induced T1DM in mice displayed typical morphological and biochemical changes, including ruptured and disorganized myofibrils and cardiac fibrosis (Fig. 2B and C), and increased serum levels of inflammatory factors (TNF‐α, IL‐1β, and IL-6) (Fig. 2D–F). This evidence concerns the gene IL6 and type 1 diabetes mellitus.