We used a genetically engineered mouse model of adult PDGFb-driven gliomas based on RCAS/Tv-a to implant primary RFP-labeled glioma cells into KO (n = 8) and respective WT control mice (n = 7), to determine the impact of host-derived GPNMB for glioma formation and growth. This evidence concerns the gene GPNMB and central nervous system cancer.