To further validate these findings, we used the FACs-presorted bulk gene expression data set published by Klemm et al. [18] GPNMB expression was analyzed in non-immune cells (CD45−), cells designated as microglia and macrophages, and neutrophils pre-sorted innate immune cell populations, stratified into respective glioma entities, namely IDHwt, IDHmut and BrM. This evidence concerns the gene GPNMB and central nervous system cancer.