We used the published bulk sequencing data of The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases to analyze the expression level of GPNMB in human glioma tissue and distinguished between primary IDH wildtype (IDHwt) and IDH mutant (IDHmut) tumors and brain metastasis (BrM). This evidence concerns the gene GPNMB and central nervous system cancer.