In the International Cancer Genome Consortium (ICGC) cohort of CLL patients, the expression of UGT2B17 correlated weakly with the expression of NF-κB subunits and STAT3 (Fig. 4A), whereas it correlated significantly with the transcriptional activity of NF-κB and STAT3, based on the expression of known gene targets for these TFs, in any tissues, as quantified by DoRothEA [23] (Fig. 4B). The gene discussed is NFKB1; the disease is B-cell chronic lymphocytic leukemia.