The expression of IRF1 did not correlate positively with UGT2B17 expression (Fig. 4A), but its transcriptional activity quantified by DoRothEA did correlate significantly with UGT2B17 expression, and correlated well with a considerable number of IRF1 gene targets in the ICGC CLL cohort (Fig. 4B,C). The gene discussed is IRF1; the disease is B-cell chronic lymphocytic leukemia.