TP53 and endometrial cancer: Numerous signaling pathways, including the PI3K/AKT/mTOR signaling pathway, WNT/β-catenin signal transduction cascades (including the APC/β-catenin pathway), the MAPK/ERK pathway, the VEGF/VEGFR ligand receptor signaling pathway, the ErbB signaling pathway, the P53/P21 signaling pathway and the P16INK4a/pRB signaling pathway, have been shown to be involved in the multiple steps of endometrial cancer development [40].