IDH1 and prostate neoplasm: A significantly greater increase in AUC profiles was observed for IDH1 (34.2 vs. 9.6, P < 0.05, Fig. 3A, C) and SMAD (48.5 vs. 15.3, P < 0.05, Additional File 2, Fig. S6A, C, left panels) after AR inhibition in prostate tumors from AA men compared to EA men.