An aberrant immune response may arise in response to systemic viral infection, circulating IFNα, exotoxins, or accumulation of insoluble protein fibrils (e.g., α -synuclein, α-Syn) [6], and type I interferons (IFN-I) have been implicated as pivotal mediators in immune responses, with elevated levels observed in patients with Parkinson’s Disease (PD), potentially leading to neurotoxic effects [7–9]. The gene discussed is IFNA1; the disease is Parkinson disease.