Mineral dust-induced gene (Mdig), an oxygen-sensitive protein, might boost tumor growth and angiogenesis through activation of EGFR/VEGF-A/VEGF-R1/R2 pathway, it impeded lymphangiogenesis by blocking the HIF-1α/VEGF-C/D/VEGFR-3 axis [52]. This evidence concerns the gene FLT4 and neoplasm.