STAT3 and non-small cell lung carcinoma: The three EGFR-TKIs reduced the expression of VEGFR-2/3, VEGF-C, and CCR7 through the JAK/STAT3 signaling pathway, FAK phosphorylation and c-Myc, this mechanism reduced NSCLC cell proliferation and metastasis to lymphatic vessels to prevent distant metastasis.