The upregulation of H6PD plays a vital role in the acid-driven purine metabolic reprogramming, conferring a propensity towards the progression of gliomas [12].BMP2 exerts a significant influence on the advancement of gliomas; it can undermine the stability of HIF-1, rendering glioma stem cells more susceptible to temozolomide therapy. The gene discussed is H6PD; the disease is glioma.