VARS2 and neoplasm: This analysis revealed that genes such as ADCY5, DRD2, SST, TAC1, SNAP25, GRIN1, ATP1A3, HSPA1A, PRKCZ, SNCA, CAPN3, TF, HBA1, CBS, GSTM2, NDUFB9, ETFB, PINK1, MAPK10, SRXN1, VARS2, CPT1B, NDUFS7, NDUFV2, SDHA, MIF, MUTYH, COX4I1, ALDH2, and PRODH were underexpressed in tumor tissues, while AGT, EGFR, CCL2, CXCL8, PLA2G2A, LTF, FTL, CXCR4, HMOX1, CD44, SPP1, MSR1, CYBB, TREM2, JUN, EGR1, HSPA5, CALR, ANXA5, GPX1, GPX7, PRDX4, MMP2, ODC1, PCNA, MMP9, LOX, TIMP1, PLAU, and SERPINE1 showed higher expression in tumor tissues (Fig. 1B).