Among 27 AD-associated genes in the tested set of genes, there were 4 AD-associated genes higher in hiPSC-A0 vs. hiPSC-AN21 (GRN, PICALM, APH1B, and CD2AP), a 2.1-fold excess from expected (hypergeometric p = 0.04). The gene discussed is PICALM; the disease is Alzheimer disease.