CASP8 and non-small cell lung carcinoma: Furthermore, to better understand the molecular process underlying the effect of NCAPD3 on the cell cycle and apoptosis in NSCLC cells, we investigated the key regulators of G0/G1 phase transition (including Cyclin D1, Ckd4, and P27) and apoptosis-related markers (including Bcl-2, Bax and Caspase-8) for detection.