UPF1 and neoplasm: Additionally, MET amplification in lung tumors induces UPF1 phosphorylation, thereby down-regulating STING expression in tumor cells by modulating the length of STING’s 1′ -UTR through UPF3, resulting in a reduced STING-mediated IFN response and a decrease in tumor-infiltrating CD8+ T and NK cells, thereby affecting the efficiency of the ICB [77].