CGAS and neoplasm: Additionally, it is worth mentioning that before STING targeted therapies can be applied in the clinic, a thorough and comprehensive evaluation of the impact of different tumor stages, tumor microenvironment and basal cGAS-STING levels on response to STING agonist therapy is needed to determine the patients who will benefit from STING agonist therapy and we need do more research on this field [67].