BRCA2 and cancer: In the cancer cohorts, we observed two recurrent VUS in BRCA2: c.2186T > C (found in a 69-year-old male from Zhejiang with mCRPC and a 74-year-old female from Shanghai with PDAC) and c.8971 C > T (found in a 28-year-old female from Hebei Province with TNBC and a 52-year-old male from Anhui Province with PDAC).