Additionally, the recurrent BRCA2 c.3847_3848del variant was identified exclusively in PDAC patients from the East (Shanghai and Anhui).This variant has also been reported in previous regional studies in the East and Southeast Han (1/2769 unselected breast cancer patient in Zhejiang [36], 1/316 prostate cancer patient in Shanghai [37], and 1/6,314 normal Macan [17]). This evidence concerns the gene BRCA2 and Familial prostate cancer.