In this descriptive study, we integrated next-generation sequencing (NGS) data of BRCA1 and BRCA2 exons from 2,080 apparently healthy individuals and 522 patients with BRCA mutation-related cancer, to reveal the unique genetic pattern of deleterious BRCA variants, including SNVs, InDels, and LGRs, in the general Chinese Han population, with a special focus in the East Han, which account for 25% population of the Chinese Han population. Here, BRCA2 is linked to cancer.