CHL1 and melanoma: As c-Jun can modulate melanoma cells plasticity [23], we examined the expression of a set of known c-Jun-regulated genes in CHL1 cells 24 h after silencing JUNI. Interestingly, c-Jun target genes known to be involved in epithelial-mesenchymal-transition (EMT), such as ZEB2 [33] and SNAI1 [34], were downregulated by JUNI silencing, whereas CDH2, which is not a known target, was not (Fig. 4A).