Disruption of the YAP/TAZ–TEAD interaction by IAG933 and YTP-75 was demonstrated by coimmunoprecipitation (Fig. 1b and Extended Data Fig. 2b) following incubation of the Hippo-altered mesothelioma cell line MSTO-211H (LATS1/LATS2 loss of function) with IAG933 or YTP-75, an IAG933 analog with a cellular potency within a similar range (Extended Data Fig. 2a). This evidence concerns the gene LATS2 and mesothelioma.