CCN1 and cancer: Consistent with the observed IAG933 activity in a subset of Hippo-unaltered cell lines (Fig. 1e), additional profiling on 263 cancer cell lines revealed higher sensitivity in cells that display high basal TEAD activity, as determined by a four-gene (CCN1, CCN2, ANKRD1 and AMOTL2) transcriptional signature (Fig. 1i).