CCN2 and mesothelioma: Furthermore, IAG933 treatment for 24 h almost completely inhibited the expression of direct TEAD target genes CCN1, ANKRD1 and CCN2 in both MSTO-211H cells and another Hippo-altered mesothelioma line NCI-H226 (NF2 loss of function), with half-maximal inhibitory concentration (IC50) values between 11 and 26 nM (Fig. 1c).