In previous work, we used a commercially available SCD inhibitor (SCDi) (Abcam, C20H22ClN3O3) with high potency (IC50 4.5 nM) and showed that intracerebroventricular infusion of this inhibitor in 3xTg-AD mice stimulated marked changes in hippocampal gene expression, a decrease in microglia activation, rescue of dendritic spines and structure, and reversal of learning and memory deficits. This evidence concerns the gene SCD and Alzheimer disease.