The in silico interaction network analysis using these 11 upregulated genes in the HCB-541 cells showed a tight network of PPI (protein–protein interaction) pathway enrichment (p = 0.00497) and functional enrichments suggesting interaction with viral myocarditis (red color), focal adhesion (blue color), VEGF signaling (green color), fluid shear stress and atherosclerosis (yellow color) and AGE-RAGE signaling pathway in diabetic complications process (pink color) (Fig. 3D). Here, RENBP is linked to atherosclerosis.