The same in silico interaction network analysis of the 26 downregulated genes PPI enrichment of p-value of 1.0e-16 and functional enrichments suggest interaction with Notch (red color), p53 signaling (blue color), Basal cell carcinoma (green color), Bladder cancer (yellow color) and ECM-receptor interactions (pink color) (Fig. 3F). This evidence concerns the gene TP53 and basal cell carcinoma.