KRT6C and Alzheimer disease: Consistent with dupilumab-associated inhibition of type 2 cytokines7, we found downregulation of inflammatory keratins KRT16, KRT6A, KRT6B, and KRT6C, and upregulation of the barrier markers IVL and SPINK5 in keratinocytes of DAHND compared to untreated AD groups (Fig. 7D).