Remarkably, overall gene expression of IL13, IL22, and AHR were highest in DAHND oligoclones, while those from untreated head/neck AD characteristically showed upregulation of the type 2-associated marker amphiregulin AREG39, and those from untreated trunk AD showed highest levels of IL26, CCL1 and CSF2 (Fig. 4I, Supplementary Data 7). The gene discussed is IL22; the disease is Alzheimer disease.