The initial “B” cluster could be further subdivided into plasma cells (PC), B cells (BC) and plasmacytoid dendritic cells (pDCs), with significant increases in MS4A1+ CD79A+ CD27- B cell and MS4A1-CD79A+ CD27+ plasma cell counts in DAHND (Fig. 2A–F) that could be confirmed in multicolor immunofluorescence stainings in an independent sample set (Fig. 2G, H, Supplementary Data 1). The gene discussed is CD27; the disease is breast cancer.