While SMC2 showed upregulation of the AD signature chemokine CCL26 as well as POSTN only in untreated head/neck and trunk AD, CCL19, a ligand of CCR7, was more abundantly detected in DAHND lesions, with concomitant increases in CCL8 expression (Fig. 9G, Supplementary Data 4), which may shape the specific inflammatory milieu in the dermis of these lesions. The gene discussed is SMC2; the disease is Alzheimer disease.