COL6A6 and Alzheimer disease: When we directly compared DAHND fibroblasts with location-matched untreated head/neck AD (Fig. 9C–F, Supplementary Data 5), we found strong downregulation of the AD-typical fibroblast markers73COL6A5 and COL6A6 particularly in FB3 and FB4 clusters of DAHND lesions (Fig. 9E, F, Supplementary Data 5), suggesting their induction by type 2 cytokines rather than constitutive expression in AD.