When calculating differential gene expression among all groups (Supplementary Data 4) or by pairwise comparison of DAHND with location-matched head/neck AD (Supplementary Data 5), DAHND samples demonstrated the strongest expression of IL22 in several T cell subsets, particularly T1 and T4 (Fig. 3F, G, Supplementary Data 4-5). Here, IL22 is linked to Alzheimer disease.