F8 and hyperinsulinemic hypoglycemia, familial, 4: Hemophilia A and B are prime examples of hematologic disorders caused by a deficiency in secreted acellular blood components.283 The estimated prevalence for hemophilia A and B are ~12:100,000 and 4:100,000, respectively.284 Hemophilia A and B are caused by factor VIII (FVIII) and factor XI (FXI) deficiency, respectively, and both are recessive X-linked conditions.285 FVIII is synthesized in endothelial cells, whereas FIX is produced in hepatocytes.286–288