LIN28B and neoplasm: In order to confirm the role of LIN28B, PCAT5, and IGF2BP3 in tumor growth in vivo, we subcutaneously injected Ishikawa or HEC-1A cells with knockdown of LIN28B, PCAT5 and IGF2BP3 respectively, or a combined knockdown of LIN28B + PCAT5 + IGF2BP3 to construct a xenograft tumor model in nude mice.