APOE and Alzheimer disease: Moreover, patients with MCI, high GM3 d18:1/20:0 blood levels, and at least one APOE4 allele also had a 40% higher rate of AD progression within two years than those with low blood levels of GM3 d18:1/20:0 and no APOE4 allele (HR = 4.6, P = 2.3 × 10–16) (Fig. 5d–g and Table 3).