Following challenge with B16 melanoma, mice that lost weight after semaglutide treatment showed only a modest response to immunotherapy (Fig. 3F, G) and no evidence of improved CD8+ TIL function (Fig. 3H, I), which is in stark contrast to the rescue of tumor immunity observed in mice with diet-induced weight loss (Fig. 2). The gene discussed is CD8A; the disease is neoplasm.