The previous study has uncovered the landscape of genomic alterations of RBPs by cross-cancer analysis.22 By utilizing online cBioPortal tool (http://www.cbioportal.org) including 19 CRC datasets, we noted that cancer-related RBP MEX3A was distinctly and significantly amplified and overexpressed in human CRCs (Fig. 1a, b). Here, MEX3A is linked to cancer.