UPF1 and acute myeloid leukemia: circNSUN2 enhances the stability of HMGA2 mRNA to promote CRC metastasis progression by forming a circNSUN2/IGF2BP2/HMGA2 RNA-protein ternary complex.18 circMYBL2 exacerbates acute myeloid leukemia by strengthening the interaction between PTBP1 and FLT3 mRNA, thus promoting translation.19 Here, we unveiled a potent mechanism through which circMPP6 can facilitate PDE5A mRNA decay by strengthening the interaction between MEX3A and UPF1, a crucial component of PBs aggresome processing.