A current study has shown that the dysregulation of SYK localized in PBs affects PBs formation during the EMT development in breast cancer.38 Abro1 and FANCD2 have been reported to disrupt the formation of replication stress-elicited PBs, which contribute to promoting the innate immune response following persistent replication stress in the osteosarcoma cell line U2OS.39 Our study provides the first evidence that MEX3A accumulates into cytoplasmic droplets formed through LLPS and recruits several structure containing factors to assemble PBs in CRC cells. Here, FANCD2 is linked to breast cancer.