A previous study demonstrated that Ube2v1 promotes the growth and metastasis of CRC by epigenetically suppressing autophagy.45 An additional report showed that PKCλ/ι activation suppresses both autophagy and IFN signaling, and thus prevents immunoevasion in CRC.46 These findings imply that autophagy may have differential influences at distinct stages of tumorigenesis. This evidence concerns the gene UBE2V1 and colorectal carcinoma.